PERBEDAAN EFEK SEDUHAN KULIT DAN JUS BUAH NAGA MERAH (Hylocereus polyrhizus)TERHADAP KADAR KOLESTEROL LDL SERUM TIKUS Sprague dawley DISLIPIDEMIA

Abstract

Background: Dyslipidemia is a condition where fat levels in the blood is not normal. Red dragon fruit (Hylocereus polyrhizus) contains polyphenols, antioxidants and fiber in high quantities. Polyphenols have the ability to lower LDL cholesterol levels in humans and rats. Aim : To determine the differences between effect of red dragon fruit’s peel steeping and flesh juice administration on serum cholesterol LDL levels of Sprague dawley rats with dyslipidemia. Methods: This research was experimental study using pre and posttest control group design. Samples were male Sprague Dawley rats with certain criteria, randomly divided into 4 groups: negative control group given only with the standard feed, the positive control given with standard feed and high cholesterol feed, two treatment groups was given with standard feed, high cholesterol feed, red dragon fruit peel steeping 9,08g/200gBW and flesh juice of red dragon fruit 1,53g/200gBW, red dragon fruit’s peel steeping and flesh juice intervention given for 14 days. Serum LDL levels were measured by CHOD-PAP and GPO-PAP methods respectively. Data then were being analyzed with paired t test and oneway ANOVA. Results: There wasn’t significant difference before and after the intervention in group K(-). However, there were significant difference before and after intervention in group K (+), P1 and P2. 14 days treatment of the red dragon fruit’s peel steeping and flesh juice can reduce levels of LDL 43.33mg/dl (43,33 ± 3,65) dan (27.56±8,01). After the intervention there were difference in cholesterol LDL levels mean value levels between groups (p = 0.000), except for K (-) with P1 (peel steeping) p = 0.640 Conclusion: 14 days treatment of red dragon fruit’s peel steeping and flesh juice with dose 9,08g/200gBW and 1,53g/200gBW were significantly decrease LDL levels (43,33 ± 3,65) and (27.56±8,01) on male sprague dawley rats with dyslipidemia. Key Words: red dragon fruit peel steeping, flesh juice of red dragon fruit, serum cholesterol LDL, dyslipidemia