HUBUNGAN MEROKOK DENGAN AGREGASI TROMBOSIT PADA MAHASISWA DI LINGKUNGAN UNIVERSITAS DIPONEGORO

Abstract

Background : Smoking is a risk factor for several diseases. One of the important mechanisms involved is an atherothrombosis process. This process can be initiated by platelet aggregation. Nicotine and other oxidants contained in cigarette smoke may induce excretion of thromboxane’s metabolites and inhibit release of nitric oxide, which have important roles to increase platelet activity. Aim : to prove the correlation between duration of smoking and platelet aggregation, and the correlation between amount of cigarette per day and platelet aggregation in college students at Diponegoro University. Methods : This study was an analytic observasional with cross sectional design. Subject of the study was 22 male smokers among college students at Diponegoro University. The sampling method of this study was consecutive sampling. Platelet aggregation test was conducted using method of peripheral blood smear. Blood sampling was performed after 12 hours of fasting. Data analysis using Pearson test and Spearman test. Results : A total of 22 healthy male smokers of mean age 21±2 years were included. The subjects had smoked an average of 10±6 cigarettes a day for 54±32 months. The mean platelet aggregation was 68±8% which was interpreted as normoaggregation. Analysis result of Pearson test showed no significant correlation between duration of smoking and platelet aggregation (p=0,189, p>0,05). Analysis result of Spearman test showed no significant correlation between amount of cigarette per day and platelet aggregation (p=0,439, p>0,05). Conclusions : There was no significant correlation between duration of smoking and platelet aggregation, and there was no significant correlation between amount of cigarette per day and platelet aggregation. Keywords : Smoking, platelet, aggregation