PENGARUH PEMBERIAN SUPLEMENTASI SUPEROXIDE DISMUTASE (SOD) TERHADAP KADAR LDL SERUM PADA LANSIA

FARIZ, DEVIAN AULIA and NGESTININGSIH, DWI and SETYAWATI, AMALLIA N (2015) PENGARUH PEMBERIAN SUPLEMENTASI SUPEROXIDE DISMUTASE (SOD) TERHADAP KADAR LDL SERUM PADA LANSIA. Undergraduate thesis, Faculty of Medicine.

[img]
Preview
PDF
309Kb
[img]PDF
Restricted to Registered users only

13Kb
[img]
Preview
PDF
160Kb
[img]
Preview
PDF
1703Kb
[img]
Preview
PDF
5Kb
[img]
Preview
PDF
532Kb
[img]
Preview
PDF
17Kb
[img]
Preview
PDF
430Kb
[img]PDF
Restricted to Registered users only

447Kb

Abstract

Background: Elderly population keep increases, especially in developing countries. Elderly has been associated with aging and increase in oxidative stress. LDL is lipoprotein within human body transporting cholesterol from liver to peripheral tissue. Free radical reaction with LDL forms ox-LDL which plays important roles in atherosclerosis production. SOD as antioxidant catalyzes dismutation of superoxide anions. SOD antioxidant properties are expected to prevent oxidation of LDL and lower serum LDL levels. Aim: Prove the effect of SOD supplementation on serum LDL levels in elder people. Methods: This research was true experimental with pre and post test control group design. Samples of 26 elder people at “Pucang Gading Social Rehabilitation Unit” were divided into 2 groups. Treatment groups (14 people) were given 250 IU/day SOD supplementation, and exercise. Control groups (12 people) were given placebo supplementation, and exercise. Both treatments were done within 8 weeks, with twice a week exercise. Data normality was tested using Saphiro-wilk test. Both groups were analyzed by Paired-T-test if data distribution is normal, and using Wilcoxon test if data distribution is abnormal. Results: There was significance decrease of serum LDL levels in treatment groups by 13,64±16,96 points with p=0,010 (p<0,05). There was a decrease of serum LDL levels by 5.50±25,44 points but not significant with p=0,470 (p>0,05) in control group. Conclusion: There was significance decrease in elderly people’s serum LDL level after 250 IU/day SOD supplementation for 8 weeks. Keywords: Superoxide dismutase(SOD), elderly people, serum LDL levels, aging.

Item Type:Thesis (Undergraduate)
Subjects:Q Science > QD Chemistry
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:46187
Deposited By:Mr/Mrs Mahasiswa FK
Deposited On:08 Oct 2015 08:36
Last Modified:08 Oct 2015 08:36

Repository Staff Only: item control page