PENGARUH PEMBERIAN SUPLEMENTASI SUPEROXIDE DISMUTASE (SOD) TERHADAP KADAR LDL SERUM PADA LANSIA

Abstract

Background: Elderly population keep increases, especially in developing countries. Elderly has been associated with aging and increase in oxidative stress. LDL is lipoprotein within human body transporting cholesterol from liver to peripheral tissue. Free radical reaction with LDL forms ox-LDL which plays important roles in atherosclerosis production. SOD as antioxidant catalyzes dismutation of superoxide anions. SOD antioxidant properties are expected to prevent oxidation of LDL and lower serum LDL levels. Aim: Prove the effect of SOD supplementation on serum LDL levels in elder people. Methods: This research was true experimental with pre and post test control group design. Samples of 26 elder people at “Pucang Gading Social Rehabilitation Unit” were divided into 2 groups. Treatment groups (14 people) were given 250 IU/day SOD supplementation, and exercise. Control groups (12 people) were given placebo supplementation, and exercise. Both treatments were done within 8 weeks, with twice a week exercise. Data normality was tested using Saphiro-wilk test. Both groups were analyzed by Paired-T-test if data distribution is normal, and using Wilcoxon test if data distribution is abnormal. Results: There was significance decrease of serum LDL levels in treatment groups by 13,64±16,96 points with p=0,010 (p<0,05). There was a decrease of serum LDL levels by 5.50±25,44 points but not significant with p=0,470 (p>0,05) in control group. Conclusion: There was significance decrease in elderly people’s serum LDL level after 250 IU/day SOD supplementation for 8 weeks. Keywords: Superoxide dismutase(SOD), elderly people, serum LDL levels, aging.