HUBUNGAN JUMLAH LIMFOSIT TOTAL DAN LIMFOSIT T CD4+ DENGAN GANGGUAN FUNGSI KOGNITIF PADA PASIEN HIV-AIDS

Abstract

Background : Department of Health of Republic Indonesia data shows that the majority of people with HIV-AIDS in Indonesia are from productive age and one of the possible complication found is cognitive function impairment related to the immunity of the patients. Objective : This study was aimed to investigate the association between total lymphocyte count and CD4+ T lymphocyte with cognitive impairment in HIVAIDS patients. Method : The design was a cross sectional study, which is conduct at Dr.Kariadi Hospital Semarang. 32 subjects are HIV-AIDS patients in within inclusion criteria: age ≥ 14 years, could reading and writing. The venous total lymphocyte count and CD4+ T lymphocyte are examined. Cognitive function was tested using MoCA-Ina. Correlation test were analyzed with Spearman’s rho, cut off value total lymphocyte count with 2x2 tabel, cut off value CD4+ T lymphocyte count with median value. Equivalent value with linier regression Result : Significant correlation was found between total lymphocyte count (r = 0,392) and CD 4+ T lymphocyte (r = 0,379) with cognitive function. Total lymphocyte count < 1331 cells/mm3 and CD4+ T lymphocyte < 208 cells/mm3 may caused early cognitive function impairment in productive age HIV-AIDS patient. Positive correlation was found between CD 4+ T lymphocyte with total lymphocyte count (r = 0,718). CD4+ T lymphocyte value 200 cells/mm3 equivalent with total lymphocyte count value 990 cells/mm3. Conclusion: Positive correlation is found between total lymphocyte and CD4+ T lymphocyte with cognitive function. Keywords : total lymphocyte count, CD4+ T lymphocyte, cognitive function, HIV-AIDS