PENGARUH KOMBINASI CYCLOPHOSPHAMIDE - TRANSFER FACTOR TERHADAP SKOR SEL T CD4+ PADA ADENOCARSINOMA MAMMAE MENCIT C3H

Abstract

Background : Transfer factor are extracts from Colostrum, which is considered as an immunostimulant oligoribonukleotida for alternative therapies. Breast cancer patients will experience a decline in the immune system. CD4+ T cells is one of the cellular immune response to cancer. Is Tansfer factor may increase the number of CD4+ T cells. Objective : To analyze the effect of cyclophosphamid-transfer factor to the number of CD4+ T cells in C3H mice mammary Adenocarcinoma. Methods : The research laboratory experimental design with "Randomized posttest only control group." Using pure C3H female 20 mice amounted. Samples were divided into 4 groups : K as a control, P1 given cyclphosphamide, P2 and P3 were given transfer factor were given a combination of cyclophosphamidetransfer factor. As the dependent variable is the number of CD4+ T cells. Analysis of differences between the four groups using ANOVA with 95% confidence level. Results : The difference in the number of CD4+ T cells obtained value of p = <0.001 between the control group (K) to the treatment group (P1, P2, P3) and between treatment groups are given a combination of Cyclophosphamide-transfer factor to the treatment group who were given Cyclophosphamide alone or transfer factor alone. There was no significant difference in the number of CD4+ T cells in treatment groups that were given Cyclophosphamide alone compared with the treatment group who were given transfer factor only. Conclusion : There is increased number of CD4+ T cells significantly in C3H mice mammary adenocarcinoma who were given cyclophosphamide-transfer factor. Keywords: Transfer Factor, cyclophosphamide, CD4+ T cells, mammary adenocarcinoma