PENGARUH PEMBERIAN EKSTRAK JAHE MERAH (Zingiber officinale var. Rubrum) TERHADAP KADAR MDA DARAH TIKUS SETELAH TERPAPAR ASAP ROKOK

Abstract

Background: The cigarette smoke is one source of free radicals. High levels of free radicals that can cause the condition of oxidative stress and lipid concentration triggered on the cell membrane which results in Malondialdehyde (MDA). In fact, the body has a number of enzymes and substances that can neutralize free radicals that are called antioxidants. High levels of free radicals can cause endogenous antioxidant is not capable to neutralize. The ability of ginger as natural antioxidants are also inseparable from the levels of the total phenolic components contained in it so it has a high protective effect in counteracting oxidative stress. Objective: This research aims to know the influence of the awarding of the Red Ginger extract against rat serum MDA levels after exposure to cigarette smoke. Methods: This research is a true experimental research with the design of pre-post test only control group design in rat. The treatment given by the giving of extracts of Red Ginger (Zingiber officinale var. Rubrum) and the granting of smoke exposure in rat, while the outputs (outcomes) is rat serum MDA levels. Results: Granting exposure to cigarette smoke in the Group 2 increase serum MDA levels compared to group 1. Group 3 are given red ginger extract 200 mg/kgBB/day ineffective to lowers levels of serum MDA. According to the group, Red ginger extracts decreases serum MDA levels as much as 3.75% after given exposure to cigarette smoke (K4) when compared to the group that was given a red ginger without any given exposure to cigarette smoke (K3), the decline was not meaningful statistically (P < 0.05). Red ginger extracts increases serum MDA levels after given exposure to cigarette smoke (K4) when compared to the group that was given exposure to cigarette smoke (K2). Conclusion: There is no meaningful influence awarding of Red Ginger (Zingiber Officinale var. Rubrum) against the levels of MDA in blood of rat after exposure to cigarette smoke. Keywords: Red Ginger Extract, exposure to cigarette smoke, serum MDA