PENGARUH PEMBERIAN DOSIS BERTINGKAT EKSTRAK KULIT BUAH NAGA PUTIH (Hylocereus undatus) TERHADAP GAMBARAN MIKROSKOPIS HEPAR MENCIT Balb/c YANG DIBERI PAPARAN ASAP OBAT NYAMUK BAKAR

Abstract

Background: The mosquito-coil smoke contains allethrin. The inhaled allethrin will encounter metabolism in liver. These toxic substances may lead to oxidative stress in liver and manifest as microscopic liver lesion. White pitaya peel has high polyphenol content. Polyphenol is an antioxidant which can act as hepatoprotector and beneficial for liver damage prevention. Aim: To prove the effect of white pitaya peel (Hylocereus undatus) extract administration on microscopic liver of the Balb/c strain mice exposed by mosquito-coil smoke. Methods: This experiment was a true experimental with post-test only control group design. Twenty five 2-3 month old, 20-30 grams weight male Balb/c strain mice, divided into 5 groups randomly. K1 was given standard food and water, K2 was given mosquito-coil smoke exposure 8 hours per day, P1, P2, and P3 were given mosquito-coil smoke exposure 8 hours per day and administration white pitaya peels extract with respectively dose 7,5mg/ml, 15mg/ml, 30mg/ml. This research was implemented for 21 days. On the 22nd day, the mice were terminated for the liver histopathology examination. Results: Post hoc tests showed significant difference between P1 with K, P2, P3, and P4 (p<0,05). P1 had more severe degree lesion than K. Compared with P1, microscopic observation lower degree lesion of P2, P3, and P4 was denoted. Conclusion: White pitaya (Hylocereus undatus) peels extract administration gives effect to the liver microscopic of Balb/c mice exposed by mosquito-coil smoke. Keywords: white pitaya peel extract, mosquito-coil smoke, microscopic, liver