PENGARUH SUPLEMENTASI ZINK TERHADAP KELUARAN KLINIS PASIEN STROKE ISKEMIK AKUT

Abstract

Background: Zink played a role in the pathophysiology of acute ischemic stroke. Patients suffering from acute ischemic stroke have significantly lover levels of zinc serum than healthy patients. Zinc decrement status is associated with poor clinical neurological outputs on acute ischemic stroke patients. Objective: To examine the effect of zinc supplementation on clinical output of acute ischemic stroke patients Methods: This study is a double blind randomize clinical trial design with two parallel groups pre and post test control group design. Samples were patients with acute ischemic stroke who were treated in the Unit Stroke Rajawali 1A RSUP Dr Kariadi Semarang. A total of 40 patients with acute ischemic stroke who agreed to follow the research and met the criteria for inclusion were split into two groups, treatment and control. On the first day of the study, the clinical outputs and initial zinc serum levels of both groups were measured. The treatment group (20 people) were given zinc supplements at the amount of 20 mg/ 8 hours for 7 days, while the control group (20 people) were treated according to standard operating procedure applied at the hospital. On the seventh day, both groups were once more observed to gain clinical outputs and serum zinc levels after treatment data Statistical test were analyzed using paired t-test, wilxocon, and spearman. Results: An increase in zinc serum levels in the treatment group occurred. The average increment in zinc serum levels in the treatment group amounted 36,2 μg/dl. This result is statistically categorized as significant value, which is 0.000. Significant improvements were obtained in the treatment group. Clinical improvement occurred in the treatment group output. The average increment in clinical output of the treatment group was 14. There is significant value between zinc supplementation and clinical outputs of acute ischemic stroke patients, which is 0.000 and passive correlation of 0.797. Conclusion: Zinc supplementation affects the clinical outputs acute ischemic stroke patients. Keywords: Acute ischemic stroke, zinc supplementation, clinical improvement