PENGARUH EKSTRAK KULIT MANGGIS TERHADAP KATALASE ORGAN HEPAR TIKUS TERPAPAR FLUFENAZIN DEKANOAT

Abstract

Background : Fluphenazine decanoate is antipsychotics usually used in long period. Long term antipsychotics treatement resulted in a decrease of the antioxidant defense levels. The mangosteen rind extract has potency as an antioxidant. In the presence of mangosteen rind extract, it will decline in the process of the ROS formation resulted in decreased of oxidative stress. Catalase enzyme was used to know the level of oxidative stress on rats which exposure by fluphenazin decanoate and given mangosteen rind extract. Aim : To analyze the effect of Garcinia mangostana rind extract on rat liver catalase enzym which exposed by fluphenazine decanoate Methods : This was an experimental research which used post test only controlled group design. Sample of this research was 24 rats divided randomly into 4 groups. Negative control group (K0) injected with sesame oil intramuscular, positive control group (K1) given mangosteen rind extract 600 mg/kgBW, P1 injected with fluphenazine decanoate intramuscular, at last P2 injected with fluphenazine decanoate and given mangosteen rind extract. The treatement was done for 28 days and proceed with catalase levels measurement. Statistical test used one way ANOVA with post hoc Bonferroni Result : By using one way ANOVA, there was significant differences among groups K0 and K1, K0 and P2, as well as the K1 and P1. Whereas among K0 and K1; P1 and P2; and P1 and P2, there was no statistically significant diffenrences. Conclusion : mangosteen rind extract increased hepatic catalase level of rats which exposed with fluphenazine decanoate. Key word: Fluphenazine decanoate, Garcinia mangostana rind extract, catalase enzyme.