PERBEDAAN NEUTROPHIL LYMPHOCYTE RATIO PADA SUBJEK BUKAN PEROKOK, PEROKOK RINGAN DAN PEROKOK SEDANGBERAT (Studi Observasional Analitik pada Mahasiswa Universitas Diponegoro)

Abstract

Background : Smoking is a serious health problem causing high morbidity and mortality. Chronic cigarette smoke exposure may induce inflammation on respiratory tract and lung parenchymal tissue. It affects total leucocyte count and differential count components. White Blood Cell Count (WBC) is a basic but sensitive way to describe inflammatory status. Neutrophil-Lymphocyte Ratio (NLR) as a development of WBC may describe the inflammatory status between the smokers well. Aim To analyze the difference of NLR value between non-smoker, light smoker and moderate-to-heavy smoker subjects. Methods Analytical and descriptive study with cross sectional design on 36 subjects classified into three groups according to Sitepoe classification of smoker; nonsmoker, light smoker and moderate-to-heavy smoker respectively. NLR was obtained by comparing absolute neutrophil and absolute lymphocyte count. One way Anova with Bonferroni Post Hoc test were used to study the difference between the mean values in different groups. Results The average NLR value of non-smoker subjects was 2,42 ± 0,51, while the average NLR value of light smoker subjects and moderate-to-heavy smoker subjects were 3,01 ± 1,29 and 2,02 ± 0,63 respectively. Bonferroni Post Hoc Test shows difference between NLR value of light smoker subjects and moderate-to-heavy subjects (p=0,030) and shows no difference between the NLR value of non-smoker subjects and the other subjects (p=0,348; p=0,821). Conclusions There is a marked difference between the NLR value of light smoker subjects and NLR value of moderate-to-heavy smoker subjects while there is no significant difference between NLR value of non-smoker subjects and NLR value of the other groups. Keywords Cigarette, Inflammation, NLR