EFEKTIVITAS KOMBINASI DUTASTERIDE DAN TEH HIJAU TERHADAP PERDARAHAN PADA BPH PASCA TURP : Kajian pengaruhnya Terhadap ekspresi Hypoxia Induced factor 1 - Alpha (HIF – 1 α) & Hematokrit (Ht)

Abstract

Background. Benign Prostate Hyperplasia (BPH) is common in elderly. LUTS are clinical symptoms that arise from BPH. TURP is one standard surgery in patients with BPH but complications during and after operation are bleeding will increase morbidity and mortality. HIF - 1 α (Hypoxia Induced Factor 1 Alpha) one trigger angiogenesis in BPH. Currently, anti-angiogenic drug research are done, both farmako and herbal therapies, such as dutasteride and green tea. However, synergism effect to anti - angiogenesis because the use of a combination of both drugs is still unknown. Aim. This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo only and their association with differences in hematocrit levels and the expression of HIF - 1α in patients with BPH were performed TURP surgery Method. Experimental study with the draft "randomized control trial " . Comparing changes between groups angiogenesis BPH patients who underwent TURP surgery to assess the expression of HIF-1 α and Δ Ht (Hematocrit) after administration of dutasteride, green tea with combination of dutasteride and green tea for 14 days. Result. The combination of dutasteride and green tea was not significant in reducing the expression of HIF - 1 α. Mean P1 group (59.32 ± 14.69); P2 group (59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal results obtained p = 0.491 walis which means the difference Percentage of HIF - 1α among the 4 groups was not significant. The mean Δ Ht P1 group (0.61 ± 0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ± 0.275). In statistical test with Mann Whitney test comparing the percentage reduction obtained Ht levels dutasteride group against group of green tea obtained p = 0.213 means that there is no significant difference. Where a significant difference to the other groups. Conclusion. The combination of dutasteride and green tea for 14 days before TURP surgery does not reduce the expression of HIF - 1α in BPH patients who underwent TURP surgery. Δ Ht significant decline in the combination group compared with other groups and might be influenced by several factors during TURP surgery. Key words : HIF – 1 α, Hematocrit, BPH, Dutasteride, Green Tea