UJI BEDA SENSITIVITAS AZITROMISIN DENGAN SEFTRIAKSON PADA KUMAN NEISSERIA GONORRHOEAE SECARA IN VITRO

Abstract

Background: The increasing tendency of Neisseria gonorrhea’s Ceftriaxoneresistant through the years had pushed medical experts to search for alternate regiment for the treatment of Gonorrhea. Azithromycin is one of the alternative options. Purpose: To assess the difference in sensitivity for Neisseria gonorrhoeae towards Azithromycin and Kanamycin in vitro. Materials & Methods: A cross sectional, analytic observational study which examined 13 subjects with positive purulent discharge. The samples undergo gram staining to find negative gram diplococcic bacteria, followed by a Thayer- Martin culture and a 24-hours incubation on 370C temperature. The colony samples were then moved to a Mueller Hinton media for both Azithromycin and Ceftriaxone sensitivity testing. After the second 24-hours incubation, any inhibition zone formed on the colony samples was being measured. Statistical analysis uses chi-square test. Result: Azithromycin has 7 (53,5%) sensitive Neisseria gonorrheae samples while the 6 (46,2%) others were resistant. Ceftriaxone were shown resistant to 12 (92,3%) samples and only 1 (7,7%) sample was sensitive. Conclusion: There is a marked difference in sensitivity for Neisseria gonorrheae towards Azithromycin and Ceftriaxone in vitro, where Azithromycin shows higher sensitivity measure. Keywords: gonorrhea, Neisseria gonorrhoeae, azithromycin, ceftriaxone