ANALISIS SITOGENETIKA PADA PASIEN DENGAN AMENORE PRIMER DI CENTER FOR BIOMEDICAL RESEARCH (CEBIOR) SEMARANG

Ira, Pirsa Hatpri Nur and Faradz, Sultana M.H. and Ariani, Mahayu Dewi (2015) ANALISIS SITOGENETIKA PADA PASIEN DENGAN AMENORE PRIMER DI CENTER FOR BIOMEDICAL RESEARCH (CEBIOR) SEMARANG. Undergraduate thesis, Faculty of Medicine.

[img]
Preview
PDF
517Kb
[img]
Preview
PDF
184Kb
[img]
Preview
PDF
471Kb
[img]
Preview
PDF
212Kb
[img]
Preview
PDF
248Kb
[img]PDF
Restricted to Registered users only

627Kb
[img]PDF
Restricted to Registered users only

222Kb
[img]
Preview
PDF
149Kb
[img]
Preview
PDF
401Kb

Abstract

Background : Primary amenorrhea is a symptom that may result from several quite different causes such as gonadal anomalies, endocrinological imbalance and specific of genetic disorders. Primary amenorrhea is one of indications for cytogenetic analysis, which have shown the importance of chromosomal abnormalities as a cause of amenorrhea. The aim of this study is to know the distribution of karyotype in patients with primary amenorrhea in Center For Biomedical Research (CEBIOR) Medical Faculty of Diponegoro University, Semarang. Subject and Method : This study was a descriptive retrospective and prospective study design. The subjects are patients with primary amenorrhea who examined in CEBIOR Semarang since January 2005 to April 2015. Results : Cytogenetic analysis were carried out to 71 patients with primary amenorrhea during January 2005 to April 2015 and identified 47(65,3%) subjects with 46, XX; 9 (12,7%) subjects with 46, XY and 16 (22,2%) subjects with numerical and structural sex chromosome aberration such as 45, X, 45, X/46, XX, 1Xq, 46, XX/ 45, X (2%) dan 46,XX (99%)/ 45, X (1%), 46,X, i(X)(q10)(85%)/45, X(15%), 45,X(76%)/46, X, i(X)(q10)(24%), 47, XY+21, 46, XX,del (9)(p23)->pter, 46, XX, t(1; X)(p34; q25), 46, XX, t(1; X)(p34; q25), and 46, XX/46, XY(10%). Conclusion : Cytogenetic analysis was done for 71 subjects and mostly subjects have 46, XX karyotype. Cytogenetic investigations are important to established the diagnoses and management for primary amenorrhea cases, although in some cases with cryptic chromosome aberrations should be investigated with molecular analysis. Keywords : Primary amenorrhea, Cytogenetic analysis

Item Type:Thesis (Undergraduate)
Subjects:Q Science > QH Natural history > QH426 Genetics
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:46289
Deposited By:Mr/Mrs Mahasiswa FK
Deposited On:30 Oct 2015 10:29
Last Modified:30 Oct 2015 10:29

Repository Staff Only: item control page