PENGARUH EKSTRAK TAPE UBI UNGU (Ipomoea batatas L.) TERHADAP KADAR AST DAN ALT DARAH TIKUS SETELAH AKTIVITAS FISIK MAKSIMAL

Abstract

Background : physical activity can cause oxidative stress and tissue damage. Lier is an important organ that has many functions. Physical activity reduces blood perfusion to the liver and can damage liver cells. Consuming exogenous antioxidants is one way to prevent cell damage from oxidative stress. Purple sweet potato (Ipomoea batatas L.) is one source of antioxidants due to the high content of antosianin. Fermentation can increase the stability of antioxidants. Aim : To investigate the effect of fermented purple sweet potato extracts (Ipomoea batatas L.) with AST and ALT levels in blood after maximal physical activity Methods : This study uses a true experimental design with post test only control group design in male rats. The research uses 24 samples of rats with 4 different treatments. The treatment whom given is fermented purple sweet potatoes extracts (Ipomoea batatas L.) and provision of maximum physical activity in rats, while the output is AST and ALT levels in rats blood. Results:Posthoc LSD test was observed that AST and ALT levels is higher and significant difference (AST: p=0,012 dan ALT: p=0,037) on rats with maximum physical activity (AST K2=241,04±49,20 / ALT K2=94,76±32,29) compare with control group (AST K1=178,28 ± 39,60/ ALT K1=68,58 ± 11,26). Group with consumption of fermented purple sweet potatoes extract for 7 days (AST K3=162,64 ± 21,76 / ALT K3=52,98 ± 7,77) have lower but not significant difference (AST: p=0,488 dan ALT: p=0,194) with control group (AST K1=178,28 ± 39,60/ ALT K1=68,58 ± 11,26). AST and ALT levels on rats who was given fermented purple sweet potatoes extract and doing maximum physical activity (AST K4=187,54 ± 20,08/ ALT K4=63,7 ± 9,82) lower and significant difference (AST: p=0,027dan ALT: p=0,016) with group who was doing maximum physical activity(AST K2=241,04±49,20 / ALT K2=94,76±32,29). Conclusion: There is a significant effect of the fermented purple sweet potato extract (Ipomoea batatas L.) with AST and ALT levels in rat blood after maximum physical activity Keywords: fermented purple sweet potatoes extract, maximum physical activity, levels of AST and ALT