PENGARUH SUPLEMENTASI KAPSUL EKSTRAK IKAN GABUS TERHADAP LAJU FILTRASI GLOMERULUS PADA SINDROM NEFROTIK RESISTEN STEROID ANAK

Abstract

Background Steroid Resistant Nephrotic Syndrome (SRNS) is one of nephrotic syndrome classification which do not respond to therapy with steroid. Children with SRNS have high risk of decline of kidney’s function. Glomerular filtration rate can be used as indicator of kidney’s function. Snakehead fish extract supplementation can increase serum albumin level, therefore is expected to increase glomerular filtration rate indirectly. Aim This study aims to prove the effect of Snakehead fish extract supplementation on glomerular filtration rate in children with SRNS aged 2-18 years old. Methods This was a quasi experimental study with pre and post design performed in the pediatric polyclinic of Kariadi General Hospital, Semarang. There were 10 patients which 3 of them drop out in the process. Patients recieved gabus-fish extract suplementation with 2x500 mg dose for 21 days. Data was statistically analyzed by paired t-test. Results The initial Glomerular filtration rate mean was 114,09 ± 41,60 ml/min/1,73 m2 decreased to 105,97 ± 33,81 ml/menit/1,73 m2 after the intervention, with differences mean of -8,12 ± 39,23 ml/menit/1,73 m2. There was no significant difference (p=0,604) in glomerular filtration rates before and after intervention. Conclusion Snakehead fish extract capsules supplementation at a dose of 2x500 mg for 21 days did not significantly change glomerular filtration rates of children with SRNS. Keywords Snakehead fish extract capsules, glomerular filtration rate, steroid resistant nephrotic syndrome