PENGARUH PEMBERIAN SUSU KAMBING TERHADAP GAMBARAN MIKROSKOPIS HEPAR DAN KADAR SGPT TIKUS WISTAR YANG TERPAPAR ASAP KENDARAAN BERMOTOR

Abstract

Background: The toxic substances in vehicle emission will encounter metabolism in liver, induce oxidative stress, inflammation, and manifest as microscopic liver lesion detected by SGPT’s elevation. Meanwhile, goat’s milk containing antioxidant and antiinflammation substances can be beneficial for preventing the liver lesion and the elevation of SGPT level due to vehicle emission exposure. Aim: To prove the effect of goat’s milk administration on liver hystopathology and SGPT level of the rats exposed by vehicle emission. Methods: True experimental post-test only controlled group design. Fifteen 2-3 month old, 100-200 grams weight male wistar rats were divided into 3 groups randomly: control group given standard food and beverage, and treated groups (P1 and P2). P1 was given vehicle emission exposure 8 hours per day. P2 was given vehicle emission exposure 8 hours per day and 473,2 mg/kgBW goat’s milk. This research was implemented for 30 days. On the 31st day, the rats’s blood was collected for measuring the SGPT level and the rats were terminated for examining the liver hystopathology. Result: Compared with control and P2, P1 had more severe degree of inflammation, degeneration, and fibrosis, also higher level of SGPT. On statistical tests for degeneration, fibrosis and SGPT were found significant differences (p<0,05) between control and P1. Compared with P1, microscopic observation denoted lower level of inflammation and fibrosis in P2 whereas it was statictically unsignificant (p>0,05). Post Hoc test represented significant difference (p<0,05) on SGPT between P1 and P2. P2 was statistically significant had lower SGPT level than P1. Conclusion: Goat’s milk administration wasn’t take effect on liver hystopathology but it was statistically effected the SGPT level of wistar rats exposed by vehicle emission. Keywords: goat’s milk, vehicle emission, microscopic, liver, SGPT