PENGARUH VITAMIN E TERHADAP KADAR SGOT DAN SGPT PADA TIKUS YANG DIBERI PARASETAMOL

Abstract

Background: paracetamol is the most published antipiretic and analgetic agent. Paracetamol produces radical metabolite that can be toxic in high dose. Vitamin E as antioxidant might protect liver from any oxidative damages. Objective: compare several doses of vitamin E in preventing AST and ALT increases. Method: The subject was 30 male Sprague dawley rat devided into 5 groups. Design was randomized pre-post test, with the independent and dependent variable was vitamin E’s dose (20,30,40,50 mg/kgbw) and AST, ALT’s level (U/l) respectively. Hepatotoxicity was gained by administration of single dose paracetamol 1.500 mg/kgbw per-oral. Data was analized by comparing means. Result: the optimal dose of vitamin E in preventing liver damage is in 20-40 mg/kgbw. The group with vitamin E 50 mg/kgbb showed no differences compared to placebo. Conclusion: vitamin E administration could decrease the SGOT and SGPT level in rats treated with paracetamol. The optimum dose was 30 mg/kgbw. Keyword: vitamin E, paracetamol, antioxidant.