QUALITY OF LIFE PADA PENDERITA LEBER HEREDITARY OPTIC NEUROPATHY (LHON)

Hanifah , Nida Nur and Sulakso, Kentar Arimadyo (2013) QUALITY OF LIFE PADA PENDERITA LEBER HEREDITARY OPTIC NEUROPATHY (LHON). Undergraduate thesis, Faculty of Medicine Diponegoro University.

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Abstract

Background: Leber Hereditary Optic Neuropathy (LHON) is maternally inherited disease that cause acute or subacute the retinal nerve fibre layer degeneration. The disease lead to the loss of central vision as the clinical manifestation. The worsening of eye condition in LHON patient may have the negative impact for their Quality of Life. Aim: to prove the existences of quality of life differences in LHON affected patient compared to normal people Method : This is an Observational-analytical study with Cross-Sectional design. The quality of life were assessed by VFQ-25 questionnaire, while the LHON diagnosed by genetical test. Age and sex matched healthy refference samples were used as comparison. The statistical test used was Wilcoxon rank-sum test. Results : 11 LHON patients were analyzed. Siginificant lower Quality of Life compared to healthy refference sample in composite score (p<0,001), general health (p=0,007), general vision (p<0,001), near activities (p<0,001), distance activities (p<0,001), social functioning (p<0,001), mental health (p<0,001), role (p=0,002), dependency(p<0,001), and color vision (p<0,001) subscale. Conclusion : the Quality of Life in Leber Hereditary Optic Neuropathy was significantly poorer than healthy refference sample. Keywords : Quality of Life, VFQ-25, LHON, DNA Mutation

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > RE Ophthalmology
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:44108
Deposited By:Ms Lutfiatun Heni
Deposited On:24 Oct 2014 08:25
Last Modified:24 Oct 2014 08:25

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