PENGARUH SINDROMA METABOLIK TERHADAP GANGGUAN FUNGSI KOGNITIF

Abstract

Background : Metabolic syndrome represents a public health problem with significant morbidity and mortality. Metabolic syndrome contributes to the decline in cognitive function. The purpose of this study was to prove association of metabolic syndrome with cognitive impairment. Method : This was a cross sectional study, which was conducted at Dr. Kariadi Hospital Semarang. Sixty one research subjects were suspected of metabolic syndrome according to NCEP ATP III criteria 2001 modificated for Asia with the criteria of age 40-65 years. Research variables were age, sex, educational level and occupation and components of metabolic syndrome. The data were statistically analyzed using unpaired t-test, Mann-Whitney, 2 and Fisher exact test. Results : The prevalence of cognitive impairment in patients with metabolic syndrome was 44.3%. The magnitude of risk for metabolic syndrome experience cognitive impairment was 4.7 (95% CI = 0.7-30.2). Three components of metabolic syndrome prevalence ratio was 4.2 (0.95-18.5), four components was 5.2 (1.3-21.3) and five components was 6.0 (0.9–40.3). Triglycerides 150 mg/dl were the most affecting factor for cognitive impairment in patients with metabolic syndrome. Conclusion : Metabolic syndrome was proven affecting cognitive impairment. There was increased risk of cognitive impairment in line with the increase in the number of positive components of metabolic syndrome. Triglyceride was the most affecting factor. Keywords : Metabolic syndrome, Cognitive