EFEK ANTI INFLAMASI-ANTI FIBROTISASI EPIGALLOCATECHIN-GALLATE (EGCG) TOPIKAL TERHADAP GAMBARAN HISTOPATOLOGIS SUBSTANSIA PROPIA KONJUNGTIVA KELINCI PASCA OPERASI FILTRASI (ANTI-INFLAMATORY AND ANTI-FIBROTIC EFFECT OF TOPICAL EPIGALLOCATECHIN-GALIATE (EGCG) AFTER FILTERING SURGERY ON RABBIT'S CONJUNCTIVAL SUBSTANSIA PROPIA HISTOPATOLOGY )

Abstract

Background : Conjungtival scarring is the most common cause of glaucoma 'filtering surgery failure. Steroid was the golden standard to prevent scar formation after filtering surgery; but it has effect on increasing intra ocular pressure. -Epigallocateehin=aidlate (EGCG) was proved to have anti infiamatory and anti fibrotic effect, but it's effect on conjungtival tissue after filtering surgery has not been stddied. Objectives : To investigate the anti inflammatory and anti fibrotic, effect of EGCG on codjunglival sUbstatitia propria, after-filtering surgery. Methods : This study was a laboratory experimental with parallel group post test only 2 groups deSign. 28 male NeWZaealand-White rabbits diVided into two groups.-The control group received topically applied steroid (dexamethason) and anti biotic, the treatment group received topically applied of 0,05 mg/niL ofEGCG after filtering surgery. After 3 weeks of treatment, the eye was enucleated and the conjungtival was examined for inflamatory and fibrotic grading on cofijungtival substantia proptia. Results : There were no statistically different of inflammatory and fibrotic grading on conjungtival subataritia propia between-EGCG and control groups. Conclusion : Application of topical EGCG gave an equal effect as topical dexametasopn on conjungtival substantia propria inflammatory and -fibrotic grading.