PENGARUH PENAMBAHAN GLISIN TERHADAP NILAI HEMATOKRIT WANITA HAMIL TRIMESTER KEDUA YANG DIBERI SUPLEMEN ZAT BESI

Abstract

Background: Anemia leads to unwanted outcomes in pregnancy, partum, and purpuerium. The most common cause of anemia in pregnancy is iron deficiency. Hematocrit may predict the severity of anemia. Glicyne, one of the components in hemoglobin synthesis, is predicted to enhance iron absorption that may increase the hematocrit value. This study was providing evidence that glycine enrichment affect the iron supplement affectivity in raising second trimester pregnant women's hematocrit value. Methods: This was a double blind randomized control trial study, blood was drawn from two randomized groups of 30 pregnant women aged 20 to 40, at second trimesters' gestation with hemoglobin under 11g/dL, then the hematocrit value was measured. The two groups then labeled as control or treatment that receive iron tablet with glycine for treatment and placebo for control during 28 days. At the end of study, blood was drawn to evaluate the difference (Independent T-test) between the control and treated groups' improvement in hematocrit value. Results: The control group gains a significant increase, but the glycine treated group shows only slight increased. Independent T-test shows that there was no significant difference of hematocrit increasing between groups. Though the compliance mean percentage was different between groups, it showed no correlation to the result. Conclusion: Glycine enrichment is proven not to be more effective than only iron supplementation in raising second trimester pregnant women's Hematocrit value.