Association of Interleukin-10 (Il-10) Serum Levels with Clinical Outcomes of Acute Ischemic Stroke Patients

Abstract

Background: The pathophysiology of ischemic stroke is closely related to the inflammatory response that directly proportional to brain tissue damage. Interleukin-10 (IL-10) is an important anti-inflammatory cytokine that arises in response to brain injury. Aim: To determine the association of serum IL-10 levels with clinical outcomes of acute ischemic stroke patients. Method: An analytical observational study with prospective cohort designs included 48 subjects of first acute ischemic stroke. On 3rd and 21stday of onset, scores of national institutes of health stroke scale (NIHSS) were assessed and venous blood was taken to measure IL-10 serum levels. Result: Among 48 subjects, 32 (66.67%) subjects had high IL-10 serum level and 16 (33.3%) had normal level. There were no significant relationships between age (p=1.000), sex (p=0.833), type of lesion (p=0.683), ECG (p=0.230), nutritional status (p=0.186), hypertension (p=0.215), diabetes mellitus (p=0.130), dyslipidemia (p=0.383), smoking status (p=0.654) and NIHSS score.The multivariate analysis obtained significant correlation between interleukin (IL)-10 (p=0.023, OR=5.456), location of non-dominant hemispheric lesions (p=0.024, OR=5.090) with NIHSS score changes. Conclusion: There was significant association between IL-10 serum levels, location of non dominant hemispheric lesion andan improvement of clinical outcomes of acute ischemic stroke patients. Keywords: Interleukin-10 serum levels,acute ischemicstroke;clinical outcomes of acute ischemic stroke patients