Immunologi Stroke Peran Inflamasi dan Imunitas pada Stroke Iskemik

PUDJONARKO, DWI (2019) Immunologi Stroke Peran Inflamasi dan Imunitas pada Stroke Iskemik. In: National Scientific Meeting Stroke 2012, November 23-25, 2012, Patra Semarang Convention Hotel.

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Abstract

Abstrak: Stroke merupakan penyebab utama kecacatan dan kematian di seluruh dunia dewasa ini. Baru belakangan ini disadari bahwa mekanisme kekebalan berkontribusi terhadap patofisiologi stroke iskemik, yang selama bertahun-tahun dianggap terutama sebagai penyakit pembuluh darah. Umumnya dianggap hanya menjadi reaksi terhadap kerusakan jaringan, peradangan semakin diakui sebagai kontributor kunci untuk patofisiologi penyakit serebrovaskular, terutama stroke yang disebabkan oleh oklusi arteri atau stroke iskemik. Selama kaskade iskemik berlangsung, kematian sel mengarah ke fase baru dari respon inflamasi. Sel-sel mati dan sekarat melepaskan "sinyal bahaya" yang mengaktifkan sistem kekebalan tubuh. Bukti terbaru menunjukkan bahwa unsur-unsur sistem kekebalan tubuh sangat erat terlibat dalam semua tahap kaskade iskemik dan melibatkan kedua sistem imun bawaan dan adaptif. Sistem kekebalan berpartisipasi dalam kerusakan otak yang dihasilkan oleh iskemia, sel otak yang rusak memberikan sebuah efek imunosupresif kuat yang mempromosikan infeksi kambuhan fatal dan mengancam kelangsungan hidup pasien stroke. Abstract: Stroke is a leading cause of adult disability and death worldwide. Only recently has it been realized that immune mechanisms contribute to the pathophysiology of ischemic stroke, which for many years was regarded mainly as a vascular disease. Commonly thought to merely be a reaction to tissue damage, inflammation has been increasingly recognized as a key contributor to the pathophysiology of cerebrovascular diseases, especially stroke caused by arterial occlusion or ischemic stroke. As the ischemic cascade progresses, cell death leads to a new phase of the inflammatory response. Dying and dead cells release “danger signals” that activate the immune system. Recent evidence suggests that elements of the immune system are intimately involved in all stages of ischemic cascade and involve both the innate and adaptive immune systems. While the immune system participates in the brain damage 2 produced by ischemia, the damaged brain, in turn, exerts a powerful immunosuppressive effect that promotes fatal intercurrent infections and threatens the survival of stroke patients.

Item Type:Conference or Workshop Item (Speech)
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:77747
Deposited By:Ms Lutfiatun Heni
Deposited On:10 Oct 2019 13:52
Last Modified:15 Jun 2020 07:25

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