IL-6 Levels in Leprosy Patients with Reversal Reactions (HASIL TURNITIN)

Abstract

Background BackgroundBackground Background : Reversal reaction is type IV hypersensitivity reaction that frequently occurs in borderline leprosy and characterized as an acute inflammation of former skin lesion. Despite the lack of sufficient studies in literature on IL-6 in leprosy patients, theory supports IL-6 mast cell production in patients with reversal reaction. However, there were no studies which compared IL-6 produced by mast cell in RR leprosy patients. AimAim : To examine the IL -6 level in reversalreversalreversalreversalreversal reversalreversal reaction reactionreactionreaction reactionreaction of leprosy and nonnonnon-reactional reactionalreactionalreactionalreactionalreactionalreactionalreactionalreactional leprosyleprosyleprosyleprosy leprosyleprosy. Methods: 56 leprosy patients consist of 28 reversal reactions patients and 28 non -reactionalreactionalreactionalreactionalreactionalreactionalreactionalreactionalreactionalreactional leprosyleprosyleprosyleprosy leprosyleprosy were assessed for level of IL -6 in mast cell by immunohistochemistry staining. The IL -6 levels in both groups were analyzed using independent samples T test. Results: IL-6 level was significantly increased in the reversal group compared to non-reversal group (mean ± SD, 3.68 ± 1.090 vs. 11.93 ± 2.372, p<0.001) Conclusion: IL -6 level is associated with reversal reaction of leprosy. Keyword: leprosy, IL-6