BEBERAPA FAKTOR RISIKO NEFROPATI DIABETIKA STADIUM 3-5 (Studi di RSUD Kendal dan RSUD Tugurejo Semarang)

WAHYUNINGSIH, Sri and NUGROHO HS, Heri and Suhartono, Suhartono (2019) BEBERAPA FAKTOR RISIKO NEFROPATI DIABETIKA STADIUM 3-5 (Studi di RSUD Kendal dan RSUD Tugurejo Semarang). Masters thesis, School of Postgraduate.

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Abstract

Latar Belakang : Nefropati diabetika merupakan penyebab utama kejadian gagal ginjal. Sebanyak 20%-40% penderita diabetes akan berkembang menjadi nefropati diabetika, jika tidak dilakukan pencegahan dengan pengelolaan faktor risikonya. Prevalensinya di populasi Asia lebih tinggi, namun masih jarang penelitian tentang faktor risiko nefropati diabetika di Indonesia. Sehingga penelitian ini bertujuan untuk mengetahui faktor-faktor risiko tersebut. Metode : Penelitian ini menggunakan desain studi kasus kontrol dengan jumlah sampel 43 kasus dan 43 kontrol dengan teknik pengambilan sampel dengan consecutive sampling. Variabel bebas meliputi riwayat keluarga menderita penyakit kardiovaskuler, lama menderita diabetes, riwayat obesitas, kadar gula darah puasa, kadar kolesterol total, status hipertensi, kebiasaan merokok, status hiperurisemia, kualitas tidur, pola konsumsi obat, aktifitas fisik dan riwayat pemakaian kontrasepsi oral. Data diolah secara univariat, bivariat dan multivariat menggunakan regresi logistik berganda Hasil : Hasil analisis regresi logistik berganda keseluruhan responden menunjukkan bahwa faktor yang terbukti merupakan faktor risiko kejadian nefropati diabetika stadium 3-5 adalah hiperurisemia (OR 9,36; 95%CI: 3,035-28,863) dan hipertensi (OR 3,75; 95%CI:1,090-12,934). Sedangkan hasil analisis regresi logistik berganda hanya pada responden wanita menunjukkan bahwa faktor yang terbukti sebagai faktor risiko adalah riwayat pemakaian kontrasepsi oral (OR 7,32; 95% CI:1,254-43,716), aktifitas fisik kurang (OR 9,49; 95%CI:1,693-53,287), hiperurisemia (OR 9,65; 95%CI :1,870-45,799), GDP>126 mg/dL (OR 14,76; 95%CI :1,487-145,846), dan adanya riwayat obesitas (OR 8,87; 95% CI:1,195-65,766). Simpulan : Faktor-faktor yang terbukti sebagai faktor risiko kejadian nefropati diabetika stadium 3-5 merupakan faktor yang dapat diperbaiki. Disarankan untuk mengelola faktor risiko sedini mungkin untuk mencegah kejadian nefropati diabetika. Kata kunci : nefropati diabetika, faktor risiko Background : Diabetic nephropathy is a major cause of renal failure. As many as 20% -40% of diabetics will develop into diabetic nephropathy, unless it prevented by the management of risk factors. Asian population have high prevalence of diabetic nephropathy, but there is still rarely research on the risk factors for diabetic nephropathy in Indonesia. So this study aimed to determined these risk factors. Method : This study used a case-control study design with a sample size of 43 cases: 43 controls by consecutive sampling technique. Independent variables were family history of cardiovascular diseases, duration of diabetes, history of obesity, fasting blood sugar levels, total cholesterol levels, hypertension status, smoking habits, hyperuricemia status, sleep quality, medicines consumption patterns, physical activity and history of oral contraception used. Data was processed with multiple logistic regression. Result : The result of multiple logistic regression analysis showed that the risk factors for diabetic nephropathy in stage 3-5 were hyperuricemia (OR:9,36; 95%CI:3.035-28.863) and hypertension (OR:3.75;95%CI:1.090-12.934). While multiple logistic regression analysis results only on female respondents indicated that the risk factors of diabetic nephropathy in stage 3-5 were history of oral contraceptive used (OR:7.32;95%CI:1.254-43.716), less physical activity (OR 9.49;95%CI:1.693-53.287), hyperuricemia (OR:9.65;95%CI:1.870-45.799), fasting blood glukosa> 126 mg/dL (OR:14.76;95% CI:1.487-145.846), and the history of obesity (OR:8.87;95%CI:1.195-65.766). Conclusion : The risk factors that significantly proved for diabetic nephropathy on stage 3-5 were modifiable risk factors. So the patients were advised to control their risk factors as soon as possible to prevent the diabetic nephropathy. Keywords: diabetic nephropathy, risk factors

Item Type:Thesis (Masters)
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:School of Postgraduate > Master Program in Epidemiology
ID Code:69875
Deposited By:Mrs Ekana Perpus Pasca
Deposited On:22 Feb 2019 11:48
Last Modified:22 Feb 2019 11:48

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