The UNDIP-UCSC campaign to culture chemically prolific gram-negative bacteria from Indonesian Jaspis sponges

McCauley, Erin and Radjasa, Ocky Karna and Trianto, Agus and Crews , Mitchell S. and Smith, Alexander and Smith, Gavin C. and Zebrinski, Paul and Sabdono, Agus and Crews, Phllip (2018) The UNDIP-UCSC campaign to culture chemically prolific gram-negative bacteria from Indonesian Jaspis sponges. The Free Internet Journal for Organic Chemistry (IV). pp. 123-131.

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Official URL: https://www.arkat-usa.org/arkivoc-journal/browse-a...

Abstract

Indonesian marine sponges, especially Jaspis cf. coriacea and Jaspis splendens are sources for families of natural products known as the bengamides and jasplakinolides, respectively. Recent research suggests that the biosynthetic origins of these pharmaceutically important compounds may not be the sponges themselves but associated Gram-negative bacteria. Therefore samples of J. cf. coriacea and J. splendens were collected to culture the bacteria responsible for such compounds. Metabolomic analysis was performed on each of the sponges collected to ensure that the bengamides and jasplakinolides were present; therefore ensuring that the biosynthetic machinery required to produce these compounds was intact in the samples. After which Gram-negative bacteria were cultured from the Jaspis sponge samples and a total of 43 unique isolates were obtained spanning 21 taxonomic genera and three taxonomic classes.

Item Type:Article
Subjects:Q Science > Q Science (General)
Divisions:Faculty of Fisheries and Marine Sciences > Department of Marine Science
ID Code:67384
Deposited By:MS. Bahry
Deposited On:30 Nov 2018 14:01
Last Modified:27 Mar 2019 10:49

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