Two New Cytotoxic Candidaspongiolides from An Indonesian Sponge

Trianto, Agus and Hermawan, Idam and Suzuka, oshimasa and Tanaka, Junichi Two New Cytotoxic Candidaspongiolides from An Indonesian Sponge. Jurnal ISRN Pharmaceutics . ISSN 2090-6145

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Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL. Purification of the extract yielded two new macrolides 2 and 3 along with known candida spongiolide (1). The structures for compounds 2 and 3 were elucidated by spectral analysis (1H,13C,COSY,HMQC, HMBC) and by comparison of their NMR data with those of 1. Compounds 2 and 3 exhibited a little more potent cytotoxicity (IC 4.7 and 19 ng/mL) than that (IC5037 ng/mL) of candida spongiolide (1) against NBT-T2 cells

Item Type:Article
Subjects:Q Science > Q Science (General)
Divisions:Faculty of Fisheries and Marine Sciences > Department of Marine Science
ID Code:64930
Deposited By:MS. Bahry
Deposited On:18 Sep 2018 22:51
Last Modified:06 Dec 2019 09:50

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