Homocystein Levels and Lipid Profile on Non-DM and DM Individuals with and without Cardiovascular Complications

Abstract

Background: Homocysteine is suspected to increase the risk of diabetes mellitus (DM) complications and is associated with CV disease. While dyslipidemia and DM are risk factors for death due to CV disease, studies on relationship between homocysteine and glycemic control were inconsistent. Objective: To analyze the difference of Hcy level and lipid profile on nonDM (Group I), DM with CV (II) and without CV (III). Methods: This crosssectional study was conducted in Dr. Kariadi Hospital Semarang from April to October 2016. Samples were recruited consecutively, of which group I consists of 26 persons, group II (30) and III (30). All of the samples aged 30-75 years old, with long DM duration of more than 5 years. Fasting and 2 hours PP blood glucose, lipid profile was analyzed with auto analyzer, while Hcy was analyzed with ELISA. Data were analyzed using independent t test. Significance is expressed at p <0.05. Results: A significant difference on Hcy level was found between group I and III (p=0.000), but not between group I and II or II and III. No significant difference was observed on total cholesterol (TC) and LDLC in all groups. Significant differences were found on HDLC level between group I and II (p=0.009); II and III (p=0.000); I and III (p=0.033). Triglyceride level on group I was significantly different compared to group II and III (p=0.030 and 0.013 respectively), but was not significantly different compared to group II and III. Conclusion: The highest Hcy level, the lowest HDL-C and the highest triglyceride level were found in DM patients with cardiovascular complication. Keywords: DM, Homocysteine, Lipid Profile, CHD