Formalin Exposure on the Rats Feeding Diet on Antioxidant Enzymatic activity and Oxidative Damage of Rats Liver Tissue

Abstract

Using formalin or formaldehyde as a illegal preservative on food and ingredient Is very danger for health because formalin is a toxic and carcinogenic substance that potent as a sources of reactive oxygen species (ROS) and free radical exogenous. The aim of this research was to know the potent of formalin toxicities that exposure through the rats feeding diet on antioxidant enzymatic activity (SOD and GSH) and effect on oxidative damages of rats hepar tissue (MDA). Twenty five of male rats of 8 to 10 weeks old, with the body weigh 100 to 120 g, were divided into 5 groups. Group I was the control group, treated with a standard pellet feeding diet without formalin. Group II, III, IV and V were administrated with treatment feeding diet with formalin content of each were 25 ppm, 50 ppm, 75 ppm and 100 ppm. The result showed that formalin exposure through the feeding diet of rats (Rattus novegicus) affect decreasing highly significantly (P<0,01) on antioxidant enzymatic (GSH) and increasing oxidative damage (MDA) of liver tissue of rat (Rattus norvegicus).