Effects of solvent properties on the Soxhlet extraction of diterpenoid lactones from Andrographis paniculata leaves

Kumoro, A. C. and Hasan, M. and Singh, H. (2009) Effects of solvent properties on the Soxhlet extraction of diterpenoid lactones from Andrographis paniculata leaves. ScienceAsia, 35 (3). pp. 306-309. ISSN 1513-1874

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Abstract

A solid-liquid extraction was performed for the leaves of Andrographis paniculata in order to obtain two bioactive components, andrographolide and deoxyandrographolide. The problem of hydrolysable components and solvent removal difficulties in the conventional extraction led us to study further the effects of solvent properties on the conventional extraction using Soxhlet method in order to determine the best solvent or solvent mixture for high extraction yield of A. paniculata. This solvent selection is very important prior to alternative extraction methods since it can be used as a preextraction solvent, main solvent, or co-solvent. Based on the yield of extract and andrographolide and deoxyandrographolide content, methanol was found to be the best solvent.

Item Type:Article
Uncontrolled Keywords:andrographolide, deoxyandrographolide, Hildebrandt solubility parameter, polarity, kalmegh
Subjects:T Technology > TP Chemical technology
Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions:Faculty of Engineering > Department of Chemical Engineering
Faculty of Engineering > Department of Chemical Engineering
ID Code:590
Deposited By:Dr. Andri Kumoro
Deposited On:29 Sep 2009 08:22
Last Modified:29 Sep 2009 08:22

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