BEBERAPA FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEMATIAN PASIEN HIV/AIDS: Studi di Kabupaten Grobogan

SUPRIJANTO, Djoko and HADISAPUTRO, Soeharyo and SETYAWAN, Henry (2016) BEBERAPA FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEMATIAN PASIEN HIV/AIDS: Studi di Kabupaten Grobogan. Masters thesis, Postgraduate Program .

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Abstract

Latar belakang: Infeksi Human Immunodeficiency Virus (HIV) dan penyakit Acquired Immunodeficiency Syndrome (AIDS) saat ini telah menjadi masalah kesehatan global yang merupakan pandemi paling destruktif, terus menjadi masalah kesehatan dan menjadi penyebab utama kematian di seluruh dunia. Angka kematian HIV/AIDS di Kabupaten Grobogan sampai dengan April 2016 sebesar 14,38%, lebih tinggi dari nasional maupun Provinsi Jawa Tengah (6,42% dan 6,90%). Penelitian ini bertujuan untuk membuktikan bahwa faktor host/penjamu sebagai faktor risiko kematian pasien HIV/AIDS. Metode: Jenis penelitian observasional dengan rancangan studi kasus kontrol. Populasi studi adalah penderita HIV/AIDS yang masih hidup dan meninggal dewasa tahun 2014-2016 sebanyak 366 penderita dengan kematian 63 kasus. Jumlah sampel sebanyak 120 sampel, dibagi menjadi 2 kelompok kasus 40 sampel diambil dengan simple random sampling dan kontrol 80 sampel dengan systematic random sampling. Analisis data dilakukan secara univariat, bivariat dengan chi-square test, dan multivariat dengan metode regresi ganda logistik. Hasil: Faktor yang terbukti sebagai faktor risiko kematian pasien HIV/AIDS adalah umur > 40 tahun (p = 0,040; OR adjusted = 11,466; 95% CI = 1,119-117,439), Indeks Massa Tubuh (IMT) < 18,5 kg/m2 (p = 0,004; OR adjusted = 40,455; 95% CI = 3,211-509,441), tanpa ARV (p = 0,001; OR adjusted = 288,100; 95% CI = 11,284-7.356,001), dan jumlah sel CD4 < 50 sel/mm3 (p = 0,009; OR adjusted 24,437; 95% CI = 2,239-266,742). Probabilitas pasien HIV/AIDS mengalami kematian dengan memiliki faktor risiko tersebut sebesar 99%. Simpulan: Faktor risiko kematian pasien HIV/AIDS adalah umur > 40 tahun, IMT < 18,5 kg/m2, tanpa ARV, dan jumlah sel CD4 < 50 sel/mm3. Saran: Bagi masyarakat untuk mewaspadai faktor risiko kematian HIV/AIDS. Dinas Kesehatan perlu memberikan penyuluhan kepada masyarakat tentang faktor risiko kematian HIV/AIDS. Kata kunci: Kematian pasien HIV/AIDS, faktor risiko, studi kasus kontrol. Background: Infection with Human Immunodeficiency Virus (HIV) and the Acquired Immunodeficiency Disease Syndrome (AIDS) has now become a health global problem that is the most destructive pandemic, continues to be a health problem and a major cause of death worldwide. The death rate of HIV/AIDS in Grobogan District until to April 2016 amounted to 14,38%, higher than the national and Central Java Province (6,42% and 6,90%). This study aims to prove that hosts factors as factors for death of HIV/AIDS patients risk. Methods: Observational research using case control study. The study population was Patients with HIV/AIDS alive and dead adult in 2014-2016 about 366 patients with 63 cases of death. The total sample of 120 samples, were divided into two groups of 40 cases of samples taken by simple random sampling and 80 control samples with systematic random sampling. Data analysis was performed using univariate, bivariate with chi-square test, and multivariate multiple logistic regression method. Results: The factors that proved to be a risk factor for death in HIV/AIDS patients were age > 40 years (p = 0.040; OR adjusted = 11.466; 95% CI = 1.119-117.439), Body Mass Index (BMI) < 18.5 kg/m2 (p = 0.004; OR adjusted = 40.455; 95% CI = 3.211-509.441), without antiretroviral drugs (p = 0.001; OR adjusted = 288.100; 95% CI = 11.284-7,356.001), and CD4 cell counts <50 cells/mm3 (p = 0.009; OR adjusted = 24.437; 95% CI = 2.239-266.742). The probability of HIV/AIDS patients suffered death by having reviews these risk factors by 99%. Conclusions: The risk factors of death in patients with HIV/AIDS were age > 40 years, BMI < 18.5 kg/m2, without ARVs and CD4 cell counts < 50 cells/mm3. Suggestion: For the public to be aware of risk factors for HIV/AIDS deaths. Health Department needs to educate more people about the risk factors for HIV/AIDS deaths. Keywords: Mortality of patients HIV/AIDS, risk factors, case-control study.

Item Type:Thesis (Masters)
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:School of Postgraduate (mixed) > Master Program in Epidemiology
ID Code:53025
Deposited By:Mrs Ekana Perpus Pasca
Deposited On:13 Apr 2017 10:31
Last Modified:13 Apr 2017 10:31

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