KERUSAKAN HEPAR DAN KADAR ENZIM KATALASE TIKUS WISTAR TERPAPAR FLUPHENAZINE DECANOATE

Abstract

Background : Fluphenazine decanoate is an anti psychotic group prescribed for typical schizophrenic for the long time usage. It can increased oxidative stress. Catalase is an enzyme that can be used as a marker for oxidative stress, can be seen from histopathology hepar cells ranged from mild damage to cell death. The research seeking damage of histopathology hepar cells and the enzyme catalase after induced by fluphenazine decanoate. Aims : To know the damage of histopathology hepar and enzyme catalase levels of wistar rat induced by fluphenazine decanoate. Methods : This experimental research used post test only control group design. 15 of male wistar rats divided randomly into 3 group, namely the control group (K) which is given with the standard diet and the injection of sesame oil, and the group treatment I (P1) is given with fluphenazine decanoate 1 mg/kgBB, whereas the group treatment II (P2) is given with fluphenazine decanoate 2 mg/kgBB. In the day of 28, rats were terminated and the hepar were taken to be made extracts for the measurement of levels of catalase and to be made histopathological slides. Results : The highest level of catalase with percentage of 62.5 and the worst histophatology damage with histopathology score of 2.5 found in the group with induced by 2 mg/kgBB dose of fluphenazine decanoate. There is a difference of the levels of catalase between control group and PI group eventhough not significantly, while the other groups showed a significant relationships. Conclusion : There is the damage of histopathology hepar on hepatic cell (as seen on hystopathological slides) and the increased levels of the enzyme catalase on wistar rats induced by 2 mg dose of fluphenazine decanoate. Keywords: Fluphenazine decanoate, anti-hepatotoxic, damage histopathology hepar, enzyme catalase