PENGARUH PEMBERIAN EKSTRAK KUNYIT (Curcuma longa) TERHADAP JUMLAH EOSINOFIL DI JARINGAN PARU PADA PENYAKIT ALERGI : Studi Eksperimental pada Mencit BALB/c yang Diinduksi Ovalbumin

Abstract

Background: Turmeric (Curcuma longa) is a spice that is often used as traditional medicine. The active ingredient of turmeric, curcumin, acts as an anti-inflammatory on the allergic reaction. Allergy is not a deadly disease, but the disease can be a global health and social economic problems. Aim: This study aimed to prove that turmeric extract influence on the number of eosinophils in the lung tissue of BALB/c mice induced by ovalbumin. Method: This was a true experimental study with post test only controlled group design. The subjects were 18 BALB/c mice, randomly divided into three groups: a negative control group, a positive control group induced by ovalbumin, and a treatment group induced by ovalbumin and administered with turmeric extract at a dose of 100 mg/kgBW. The extract was orally given with sonde for 16 days. At the end of the study mice were terminated, the lung was taken for histopathological examination, and the number of eosinophils calculated in the peribronkhial tissue of lung. Result: This study showed significant differences between the negative control group, the positive control group, and the treatment group (p=0,000). The mean of the number of eosinophils was significantly higher in the positive control group compared to the negative control group (p=0,000) dan significantly lower in the treatment group compared to the positive control group (p=0,016). Conclusion: The turmeric extract can reduce the number of eosinophils in the lung tissue of mice induced by ovalbumin. Keywords: Turmeric extract, eosinophil, mice model of allergy