Distribusi Geografis dan Tingkat Keparahan Pasien Karsinoma Hepatoseluler Etiologi Virus Hepatitis B di RS.Dr Kariadi

Abstract

Background: Hepatocellular carcinoma is ranked fifth in all malignancy worldwide. HCC is 10-20% of all liver disease in Indonesia. There is no geographic distribution data of HCC patients with Hepatitis B virus as etiology in Central Java. Objective: Analyzing geographic distribution and the correlation between patient’s place of origin with severity index of HCC with Hepatitis B virus as etiology in RSUP Dr Kariadi Semarang, Methods: Retrospective study using RSUP Dr Kariadi HCC patient’s medical record within 2013-2015. Analyzed variables were geographic distribution of the patients (urban/rural), clinical characteristic: age, sex, severity: child-pugh score, BCLC staging, and AFP level. The data was processed with SPSS program, with significant value p<0,05. Results: There were 103 HCC patients with most place of origin included Demak(22,3%), Semarang (17,5%), Grobogan (14,6%). Male : female ratio 4,4 : 1, Group age mean 47±12,8, Child-Pugh A, 14 (13,6%) , Child-Pugh B, 54 (52,4%), Child-Pugh C 35 (34,0%) , 7 (6,8%) BCLC A (early stage), BCLC B (intermediate stage)41 (39,8%) . BCLC C (advanced stage) 21 (20,4%) . 34(33%) BCLC D (terminal stage). AFP 70% > 400. There was no significant correlation between geographic distribution with clinical characteristic and severity. Conclusion: There was no significant correlation between geographic distribution with clinical characteristic and HCC’s severity (age, sex, BCLC staging, Child-Pugh level, and AFP level). Key words: hepatocellular carcinoma, geographic distribution, severity index