Pengaruh Ekstrak Daun Dewa (Gynura Divaricata) Terhadap Kadar Ureum Dan Kreatinin : Studi Eksperimental Pada Tikus Model Kanker Payudara

Abstract

Background : The use of herbs as medicine is quite high including for breast cancer therapy. One of the herbs which is used for breast cancer treatment is dewa leaves (Gynura divaricata). Kidney has important roles in excreting drugs. Blood ureum and creatinine can be used as parameters of kidney function. There is still no literature about effects of Gynura divaricata on kidney. Aim : To determine effects of dewa leaves extract on ureum and creatinine in breast cancer model rat Methods : Experimental study Post Test Only Control Group Design. Fifteen female Sprague Dawley rats were divided into three groups. Those are negative control (K1) which consisted of normal rats, positive control (K2) which consisted of breast cancer model rats, and treatment group (P) which consisted of breast cancer model rats receiving 750 mg/kgBW/day dewa leaves extract for 14 days. After 14 days, blood was taken to check ureum and creatinine level. Results : The mean of ureum level were 54,02 for K1; 43,06 for K2; and 33,98 for P. One way ANOVA analysis showed significant differences (p=0,001). Post hoc Bonferroni analysis showed that there were no significant differences between K2 and P. Creatinine level mean were 0,44 for K1; 0,55 for K2; and 0,42 for P. Kruskal-Wallis analysis showed non significant differences (p=0,08). Conclusions : Dewa leaves extract has not been proven to affect ureum and creatinine level in breast cancer model rats. Keyword : Gynura divaricata, breast cancer, ureum level, creatinine level