POLA KEJADIAN PENYAKIT KOMORBID DAN EFEK SAMPING OAT PADA PASIEN TUBERKULOSIS DI RSUP DR. KARIADI

Abstract

Background : Tuberculosis has a high prevalence in Indonesia.Management of tuberculosis require antituberculosis drug combination strategy. However, side effects of these drugs sometimes interrupts treatment process. These side effects can be affected by many factors, for example comorbidites. Aim : To identity the pattern of comorbidites and side effects of first line antituberculosis drugs in RSUP dr. Kariadi Methods : This study was using descriptive observational with cross sectional design. Samples of this study were medical records of tuberculosis patients underwent treatment using first line antituberculosis drugs in Kariadi General Hospital in 2015. Results : There were 167 cases that met the inclusion criteria. From these samples, 30 cases experienced side effects. Most side effects cases were vomitus and nausea (12 cases). From these 30 samples, 18 samples had comorbidities, mostly diabetes. Characteristic of those with side effects were mostly women (53,5%), with age ranged from 40-59 years (53,3%), treatment duration 3-4 months (43,4%), and BMI <18,5 (70%). Comorbidities didn’t have any significant relation with side effects of antituberculosis drugs. (p=0,871) Conclusions : Samples with side effects are 18% from total samples, with vomitus and nausea be the most common. Comorbidites are around 58,7% of total samples, mostly HIV. Comorbities from samples with side effects are 60% and mostly diabetes. Characteristic of those with side effects were women, with age ranged from 40-59 years, treatment duration 3-4 months, and BMI <18,5. Comorbities didn’t have any significant relation with side effects Keywords : tuberculosis, first line antituberculosis drug, side effects, comorbities, age, gender, treatment duration, BMI