PERBANDINGAN PEMAKAIAN CEFTRIAXONE TERHADAP INFEKSI LUKA OPERASI PADA PASIEN APENDISITIS AKUT NON KOMPLIKATA YANG DILAKUKAN LAPARATOMI DAN LAPARASKOPI APENDIKTOMI

Abstract

Background : many antibiotics ceftriaxone in the patiens of non complication acute appendicitis were performed laparascopy and laparotomy appendectomy feared to be one surgical site infection. Ceftriaxone has a good therapeutic index. However that broad spectrum antibiotic is feared to kill the normal flora. It is feared could lead the antibiotic resistance and the number of surgical site infections is increasing. Aim : to know the differences between using ceftriaxone and non ceftriaxone antibiotic against surgical site infection (SSi) in the patients of acute appendicitis non complication was conducted laparascopy and laparotomy appendectomy. Methods : the study was conducted by using medical record of RSUP Dr.Kariadi 2013-2016. Retrieval data taken by the group given ceftriaxone and non ceftriaxone prophylactic antibiotic conducted by laparascopy and laparotomy appendectomy. These data was tested by non parametric Mann-Whitney test two unpaired categorical variable between ceftriaxone and non ceftriaxone antibiotic with sign of surgical site infection. Both variables were analyzed by the group as a whole, laparoscopy and laparotomy. Afterwards seen the value of its significance. Results : the amount of patient conducted appendectomy laparotomy was 54,8% (17/31). 17 of total appendectomy laparotomy patients, 70,5% was given ceftriaxone antibiotic and 11,7% was non ceftriaxone antibiotic. Whereas the amount of patients was conducted appendectomy laparascopy was 45,2% (14/31). 14 of the totals which conducted appendectomy laparascopy, 64,2% was given ceftriaxone antibiotic and 35,7% non ceftriaxone antibiotic. There was no significant difference between using ceftriaxone and non ceftriaxone to surgical site infection after conducted appendectomy laparotomy (p=0,793). There was no significant difference between using ceftriaxone and non ceftriaxone to surgical site infection after conducted appendectomy laparoscopy (p=0,273) Conclusions : there was no significant difference between the incidence of surgical site infection between using ceftriaxone and non ceftriaxone which was performed by laparoscopy appendectomy and laparotomy appendectomy. Keywords : Ceftriaxone, non ceftriaxone, laparoscopy, laparotomy, surgical site infection (SSi)