PENGARUH PEMBERIAN INJEKSI KETOROLAC INTRAPERITONEAL TERHADAP PENYEMBUHAN FRAKTUR KRURIS TIKUS WISTAR DEWASA

Abstract

Background: Non-steroidal anti inflamatory drugs (NSAID) have been proven effective for pain management in fracture cases. However, studies had shown that long term usage of NSAID could retard bone healing. Ketorolac, a non-specific NSAID, is one of the most used for analgesic in fracture cases. The recommended maximum duration of its use is 5 days, since usage beyond that is associated with detrimental side effects. It is not yet known whether ketorolac usage for 5 days could impede fracture healing. Objective: To investigate the effects of ketorolac intraperitoneal injection on fracture healing in adult wistar rats Methods: This experiment used post-test only control group design. A sample of 20 adult wistar rats are randomly divided into 2 groups, control and intervention. The subjecs had their right cruris fractured using closed fracturisation technique and given gypsum spalk for external fixation. The control group were fed ad libitum food and water for 21 days. The intervention group were given 5mg/kgBB ketorolac intraperitoneal injection daily for the first 5 days, and fed ad libitum food and water for 21 days. On the 22nd day subjects were terminated with ether-choloform overdose, and the right tibias were harvested for histological assessment, using a modified Allen fracture healing scoring system. Results: The intervention group showed a significant delay in fracture healing with mean callus score of 3.67±0.274, as compared to the control group with mean callus score of 4.38±0.302. Independent t-test showed a significant difference between the 2 groups with p=0.0001. Conclusion: Ketorolac intraperitoneal injection for 5 days could delay fracture healing in adult wistar rats. Keywords: Fracture healing, ketorolac, callus