PENGARUH PEMBERIAN DOSIS BERTINGKAT EKSTRAK KULIT BUAH NAGA PUTIH (Hylocereus undatus) TERHADAP GAMBARAN MIKROSKOPIS PARU MENCIT Balb/c YANG DIBERI PAPARAN ASAP OBAT NYAMUK BAKAR

Abstract

Background: The use of mosquito-coil are quite high. Mosquito-coil contains a chemical substance allethrin and its combustion produces Polycyclic Aromatic Hydrocarbon, carbonmonoxide, carbondioxide, nitrogen oxides, and aldehydes. Mosquito-coil smoke trigger infiltration of inflammatory cell and destruction of alveoli, causes lungs damage. White pitaya peels underutilized in use though have high polyphenol content that can act as lungs damage prevention. Aim: To analyze the effect of white pitaya peels (Hylocereus undatus) extract on microscopic lungs damage of the Balb/c mice exposed by mosquito-coil smoke. Methods: This research was used True experimental post-test only control group design. The samples were 25 Balb/c mice with certain criteria, divided into 5 groups. K1 was untreated group, K2 was given mosquito-coil smoke exposure 8 hours per day, P1, P2, P3 were given mosquito-coil smoke exposure 8 hours per day and were given white pitaya peels extract with respectively doses 7.5 mg/mL, 15 mg/mL, 30 mg/mL. This research was lasted 21 days. On the 22nd day, the mice were terminated and put its lungs to be examined microscopically. Result: Mann-Whitney test showed there were significant differences groups of K1-K2, K2-P1 and K2-P3 (p <0.05). K2 had more severe degree damage than the K1 and P1, P3 showed more lighter degree damage than K2. There was no significant difference groups of P1- P2- P3 and K2-P2. Conclusion: The white pitaya peels extracts decrease the damage of lungs microscopic of Balb/c mice exposed by mosquito-coil smoke. Keywords: lungs, pitaya peels, mosquito-coil, antioxidant, polyphenol.