PENGARUH PEMBERIAN RANITIDIN TERHADAP GAMBARAN HISTOPATOLOGI GASTER TIKUS WISTAR PADA PEMBERIAN METANOL DOSIS BERTINGKAT

Putra, Firly Syah and Saebani, Saebani and Suharto, Gatot (2016) PENGARUH PEMBERIAN RANITIDIN TERHADAP GAMBARAN HISTOPATOLOGI GASTER TIKUS WISTAR PADA PEMBERIAN METANOL DOSIS BERTINGKAT. Undergraduate thesis, Diponegoro University.

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Abstract

Background : Methanol is the simplest alcohol . Methanol is often misused as a substitute for alcohol in the form of drinks adulterated because the price is cheap. Abuse of this methanol poisoning is harmful to the body and cause death . Aim : To determine the effectiveness of ranitidine against gastric damage level Wistar rats induced dose -rise methanol . Methods : This research is a research laboratory experimental research design with post test only control group design. The number of samples was 35 mice with certain criteria , divided into 7 groups . 1 group as a negative control , untreated , as a positive control 3 groups , was given a dose of methanol -rise , as a treatment 3 groups, given methanol multilevel dose and ranitidine . Giving methanol done orally with a gastric sonde . While the provision of Ranitidine was injected intraperitoneally with a syringe . Statistical test using the Kruskal Wallis and Mann - Whitney test . Results : At the Mann-Whitney test between the negative control group to the treatment groups there were significant differences ( p < 0.05 ) . In the comparison group II and V is not found significant difference ( p = 0.55 ) . In addition , the comparison group III and VI is not found significant difference ( p = 0.747 ) . However, a comparison group IV and VII obtained significant difference ( p = 0.012 ) , but not in accordance with the hypothesis . Conclusion : Giving ranitidine in Wistar rats after exposed to graded doses of methanol can not prevent the toxic effects of methanol on Wistar rat gastric . Keywords: methanol , ranitidine , gastric histopathologic pictures

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:50514
Deposited By:Ms Lutfiatun Heni
Deposited On:19 Oct 2016 14:40
Last Modified:19 Oct 2016 14:40

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