FAKTOR – FAKTOR PREDIKTOR MORTALITAS SEPSIS DAN SYOK SEPSIS DI ICU RSUP DR KARIADI

Abstract

Background : Sepsis and septic shock are complex and multifactorial syndrome, which incidence, morbidity, and mortality remains high around the world. There are factors that considered to be responsible in sepsis severity, such as : age, sex, infection site, APACHE II score, qSOFA score, leukocyte count, hemoglobin level, hematocrit level, platelet count, glucose level, albumin level, creatinine level, systolic, heart rate, respiratory rate, PaO2/FiO2, and comorbidities. Objective : To determine predictors of mortality in sepsis and septic shock. Methods : The study was an observational analytic study with case-control method, which was conducted from April-May 2016. Cases were patients with sepsis and septic shock who died after undergone treatment in the ICU at RSUP Dr. Kariadi, while controls were sepsis and septic shock patients who survive after undergone treatment in the ICU or hospital ward at RSUP Dr. Kariadi. The data were taken from patients’ medical record and then were analyzed using univariate and bivariate with SPSS 21. Results : Forty patients as cases and 7 patients as controls were included. Fisher’s exact test had been done to determine the significance correlation between each variable with mortality and the result was : age (p = 0.553 [OR = 1.346]), gender (p = 0.623 [OR = 1.091]), infection site (p = 0.285 [OR = 2.2220]), APACHE II score(p = 0.488 [OR = 2.056]), qSOFA score (p = 0.501 [OR = 0.667]), leukocyte count (p = 0.291 [OR = 2.250]), hemoglobin and hematocrit level (p = 0.473 [OR = 0.5]), platelet count (p = 0.574 [OR = 1.206]), glucose level (p = 0.394 [OR = 1.750]), albumin level (p = 0.357), serum creatinine level (p = 0.606 [OR = 0.831]), systolic (p = 0.190 [OR = 3.056]), heart rate (p = 0.525 [OR = 0.75]), respiratory rate (p = 0.499 [OR = 1.393]), PaO2/FiO2 (p = 0.426 [OR = 1.630]), and comorbidities (p = 0.660 [OR = 0.786]). Conclusion : There were no significantly correlation among variables with mortality in sepsis and septic shock patients. This result had weakness as there were not enough samples so it couldn’t represent the whole population. In addition, there were other variables that were expected to be potential as mortality predictors of sepsis and septic shock yet were not studied because limitation of data. Keywords : sepsis, septic shock, predictor factor of mortality