EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE IN DISLIPIDEMIC PATIENTS A Study On The Employees Of Professor Doctor Margono Soekarjo Hospital Purwokerto

Abstract

The prevalence of dislipidemia in Indonesia increase lately. Vitamin E as the antioxidants have important role in increasing cholesterol metabolism, protecting Low Density Lipoprotein (LDL) cholesterol against oxidation and increasing level of High Density Lipoprotein (HDL). The aim of this study was to investigate the effect of vitamin E supplementation on lipid profile in dislipidemic patients. The study was a Randomised Controlled Clinical Trial. Subjects were the employees of Professor Doctor Margono Soekarjo hospital, Purwokerto aged 30-50 years who suffered from dislipidemic with a minimal risks. All subjects (42 persons) were divided into 2 groups, supplementation and control groups. The supplementation groups received 400 IU vitamin E once a day for 30 days and the control group received placebo once a day for 30 days. Data on characteristics (age, sex and BMI) were collected through interview, weight and height measurement. Lipid profile was examined before and after supplementation by vitros system chemistry analyser 250 dan 350. Data on nutritional intake were gathered using food recall method and processed Nutrisurvey. Analysis were conducted by t-test, mann whitney, wilcoxon and chi square tests.