PENGARUH PEMBERIAN EKSTRAK KAEMFERIA GALANGA L(KENCUR) TERHADAP EKSPRESI COX-2 DAN PENGHAMBATAN UKURAN TUMOR PADA ADENOKARSINOMA MAMMA MENCIT C3H

Abstract

Background: Treatment of breast cancer using traditional plant are still used by patients. We want to know effect of kencur extract (Kaemferia Galanga L) or etil p- metiksisinamat which has effect. as anti inflammation. Inflammation is one of the causes of cancer because it can increase the growth of abnormal cells that improve cancer cells Methods: pre and post test design on 24 C3H mices was divided into 4 groups: group 1(K, control), group 2(PI, kencur extract 100mg/kgBW/day), group 2(PII, 150mg/kgBW/day), group 3(PIII, 200mg/kgBW/day). After tumor inoculation, initial tumor diameter was measured, given treatment for 3 weeks, post treatment tumor diameter measurement, and then measuring Cox-2 expression. Anova test was conducted and then Post Hoc correlation test. Results: Found out decreased on Cox-2 expression variable between groups with overall p<0.001 (significant). Tumor diameter difference with variable difference test showed significant result for group K(p= <0,001), PI(p= <0,001), PII(p=0.021)and group, but insignificant for group PIII(p=0.021).We found mean decrease of Cox-2 expression (K=37,8;PI=30,0;PII=25,4;PIII=22,5) and mean decrease of tumor diameter difference (K=4,78;PI=3,16;PII=2,17;PIII=1,29),and with Spearman correlation test found significant possitive correlation(p= < 0,001) with correlation coefficient (r=0.436 very strong). Conclusion: Kencur extract decrease expression of Cox-2 adenocarcinoma C3H mice significantly, as well as inhibiting the growth of tumor mass is offset diameter of the tumor. Spearman correlation test showed a decrease in the expression of Cox-2 and decrease the difference in tumor diameter was significantly associated with the strength of the correlation is very strong. Keywords: Kencur (Kaemferia Galanga L), Cox 2 expression, diameter of the tumor, adenocarcinoma mammae