KETERLIBATAN ORGAN PADA PASIEN LEPTOSPIROSIS DI RSUP DR KARIADI SEMARANG (Perbedaan Keterlibatan Organ pada Pasien Leptospirosis Ikterik dan Leptospirosis Anikterik)

Abstract

Background: Leptospirosis is a zoonotic disease that is widespread in the world. The incidence of leptospirosis in Indonesia, especially in Semarang is still quite high and leptospirosis can cause organ involvement that can increase patient morbidity. Purpose: Measuring organ involvement in patients with leptospirosis in the Hospital Dr. Kariadi and analyze differences in organ involvement in icteric leptospirosis and anicteric leptospirosis patients. Methods: This study is a descriptive analytic. Data were taken from the case record form of clinical research data leptospirosis Hospital Dr. Kariadi. Subjects were all patients with confirmed leptospirosis, with a total of 84 patients. Diagnosis is made by MAT. Differences in hepatic involvement, renal, pulmonary and cardiac were analyzed by Fisher's Exact test, while the difference in hematologic organ involvement were analyzed by Kolmogorov Smirnof 2 samples. Results: In patients with icteric leptospirosis, organ involvement is the hepatic appears most 100%, followed by renal 98.3%, hematologic 74.1%, cardiac 32.8%, and pulmonary 32.8%. In anicteric leptospirosis patients, organ involvement is the most widely renal 76.9%, followed by hepatic 73.1%, hematologic 53.8%, pulmonary 23.1% and cardiac 23.1%. There is a difference between renal and hepatic involvement in patients with icteric and anicteric leptospirosis (p <0.05). There is no difference between pulmonary, cardiac, and hematologic involvement in patients with icteric and anicteric leptospirosis (p> 0.05). Conclusion: There is a difference between kidney and liver involvement in icteric leptospirosis and anikteric leptospirosis patiens. There is no difference between pulmonary, cardiac and hematologic involvement in icteric leptospirosis and anikteric leptospirosis patients. Keywords: Leptospirosis, organ involvement