PERBEDAAN PROFIL LABORATORIUM PENYAKIT DEMAM BERDARAH DENGUE (DBD) ANAK DAN DEWASA PADA FASE KRITIS

Abstract

Background: Dengue Haemorrhagic Fever (DHF) is a tropical infectious disease that often affects children and adults. The prevalence of DHF continues to increase every year. One of the major manifestations of DHF is hypovolemic shock caused by plasma leakage. Children may be less able to compensate the plasma leakage than adults so they have greater risk of shock. Laboratory tests are used to determine the state of hemoconcentration and thrombocytopenia of patients with DHF, especially in the critical phase to monitor and prevent the patient become worse. Objective: To analyze the differences in laboratory profile of hemoconcentration, leukopeny, and thrombocytopenia of children and adults with DHF in the critical phase. Methods: The study was observational analytic with retrospective cross sectional design. It included 70 samples of children and 70 samples of adult with DHF. Data was taken at the Dr. Kariadi Hospital. The research instrument was medical records of children and adults patients with DHF in the critical phase. Results: In children, laboratory profile of hematocrit increased as much as 63.3%, while in adult as much as 36.7%(p=0.006). Laboratory profile of leukocytes in children decreased by 48.5% and 51.5% in adults (p=0.735). Laboratory profile of platelets in children decreased by 56.7% and 43.3% in adults (p=0.007). Conclusions: There are significant differences between hemoconcentration and thrombocytopenia laboratory profiles of children and adults in the critical phase but there is no significant difference between leukopeny laboratory profiles of children and adults in the critical phase. Keywords: DHF, laboratory profiles, critical phase, children, adults