EFEKTIVITAS EKSTRAK KULIT MANGGIS (Garcinia mangostana) TERHADAP JUMLAH SEL NK DAN KADAR IFN-γ PADA PENDERITA HIV DENGAN TERAPI ANTIRETROVIRAL

Abstract

Background: Mangosteen peel contains a xanthone as strong antioxidant, which is useful as a prooxidant balancer (reduxing radicals, oxidizing radicals, carbondentered, UV light, metal, etc) that can be found in human environment. The activity of xathone can be found from the number of NK cell that will increase the production of IFN-γ cytokine. Methods: The human experimental research has been done by Randomized Control Group Pretest-Post Test Design, 20 patients sample for each group. Group 1: The HIV patients with ARV therapy were given mangosteen peel extract, 2: The HIV patients with ARV therapy were given placebo capsule. The treatment was done for 30 days, then NK cells number and IFN-γ level examination was done in pre – post treatment. The result was tested to find out the normality of data distribution by Saphiro Wilks test. If the data distribution is normal, the data analysis was continued by Paired Sample T Test to determine the difference between the pre test nad post test treatment. If the data distribution is abnormal, data analysis was continued by Wilcoxon Smith test. And Spearman’s Rho test was used to determine the correlation between the number of NK cells and IFN-γ level. Whereas the Mann Whitney test was used to determine the difference between the group 1 and group 2. Results: There are no significant differences between NK cell number (p:0.911) and IFN-γ level (p:0.588) to HIV patients with ARV therapy in the pre and post test examination after having been given mangosteen (Garcinia mangostana) peel extract. There are no significant correlations between NK cell number and IFN-γ level in each group (p: 0.074). Conclusions: There are no effects of giving mangosteen (Garcinia mangostana) peel extract on the number of NK cell and level of IFN-γ to HIV patients by antiretroviral therapy. Key Word: Mangosteen (Garcinia mangostana) Peel Extract, NK Cell Number, INF-γ Cytokin.