Effect Of Mangosteen (Garcinia Mangostana) Peel Extract Towards CD8 + T Lymphocytes And CD8 + CD38 Expression In HIV Patients With Antiretroviral Therapy

Abstract

ABSTRACT Background : HIV/AIDS still being an emerging disease and the AIDS epidemic in Indonesia is one of the fastest growing in Asia. Humans infected with HIV have been shown to be under chronic oxidative stress. Antioxidant, may have a role in the treatment of HIV infection. Experimental studies have shown that obtained xanthones from mangosteen have remarkable biological activities as antioxidant. Methods : 40 HIV-positive patients with antiretroviral therapy randomized and divided into two group; treatment group (n=20) and placebo group (n=20). Mangosteen (Garcinia mangostana) peel extract given in dose 3x800 mg for 30 days as same as placebo. The number of CD8 + T cells and CD8 + CD38 expression measures before and after treatment by FacsCalibur Becton-Dickinson flowcytometry. Results : There were no significant changes in the number of CD8 + T cells from baseline (p=0.601) and no significant differences changes of CD8 + T cells between extract group compare to placebo group (p=0.703). There were significant decrease in the level of of CD38 expression from baseline (p=0.001) but there were no significant differences from extract group compare to placebo group (p=0.495). Conclussion : Mangosteen (Garcinia mangostana) peel extract has no effects towards the number of CD8 + T lymphocytes and the level of CD8 + CD38 expression in HIV patients with antiretroviral therapy. Keywords : HIV, mangosteen peel extract, CD8 + T cells, CD8 + CD38 expression.