HUBUNGAN HBA1C DENGAN TRIGLISERIDA, LDL-K DAN APO B PADA PENDERITA DM DENGAN KOMPLIKASI JANTUNG KORONER

Abstract

Background: Glycated hemoglobin (HbA1C) can reflect cumulative blood glucose in period of 2-3 months. Dyslipidemia in diabetes have characteristics by increased levels of triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and decreased high density lipoprotein cholesterol (HDL-C). LDL-C is a lipoprotein proatherogenic, and each LDL-C has apolipoprotein B (apo B) which is an atherogenic particles. Increased HbA1C, TG, LDL-C and apo B in DM facilitate the occurrence of coronary heart disease (CHD). Objective: To determine whether there are any correlations of HbA1C level with TG, LDL-C and apo B in diabetic patients with CHD complications. Methods of research: A cross-sectional study was performed on thirty diabetic patients with CHD complications. HbA1C level test was done by ion-exchange HPLC method, TG and LDL-C levels were using colorimetric enzymatic method and apo B level using immunoturbidimetry method. Statistical analysis between the variables were analyzed using Pearson correlation test. Results: The HbA1C level <7% by 6 respondents (20%) and HbA1C ≥7% by 24 respondents (80%). The mean of HbA1C level is 8,72%, TG is 182,54 mg/dl, LDL-C is 110,64 mg/dl and apo B is 111,88 mg/dl. The relationship between HbA1C with TG has r=0.375, p=0.021, HbA1C with LDL-C has r=0.283, p=0.650 and HbA1C with apo B has r=0.574, p=0.000. Conclusion: The HbA1C levels showed a moderate positive correlation with TG levels, HbA1C levels showed a strong positive correlation with apo B levels but there is no correlation with LDL-C levels. Keywords: DM, CAD, HbA1C, TG, LDL-C, ap