PENINGKATAN PARAMETER HEMORHEOLOGI DAN C-REACTIVE PROTEIN BERKORELASI DENGAN BERBAGAI DERAJAT STENOSIS JANTUNG KORONER

Abstract

Background : Endotel dysfunction plays important role in the atherosclerosis formation before the inflammation process occurs. This endotel dysfunction is strongly related to the increment of blood viscosity (BV) thorough shear stress changes. C-reactive protein (CRP) is a biomarker inflammation and plays as a key in endotel dysfunction, formation and atherosclerosis plaque's progression. Objective : To know about the relation among BV and CRP with various degree of cardiac coronary stenosis. Method : There were twenty four patients with coronary heart disease who were taken angiography. BV levels were checked using Oswald viscometer and CRP by turbidimetric imunoassay. Angiography examination had been used to determine degree of coronary stenosis. The data had been analysed by using the Spearman correlation index. Result : The subject of this research consist of 17 men and 7 women with age in average of 55,96±7,29 years. It is found by angiography examination that there were 2 subjects (8,3%) non-significant stenosis, 22 others (91,7%) significant stenosis, and no one of them had normal stenosis. The correlation between BV and degree of coronary stenosis was moderate (r = 0,549; p = 0,005). The correlation between CRP and degree of coronary stenosis was moderate as well (r = 0,481; p = 0,017). Conclusion : There is an moderate positive correlation between BV and the degree of cardiac coronary stenosis. The similar correlation occurs between CRP and those degrees as well. Keywords : coronary heart disease, endotel dysfunction, C-reactive protein (CRP), blood viscosity, atherosclerosis, shear stress.